Holden Caulfield

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School Uniform Persuasive Essay by Javairia Haq

School Uniform Persuasive Essay At a school, a child wearing a stained ragged-patched up sweat shirt and old tired pants full of disgusting mud stains, she goes to her locker quietly, suddenly after getting out her books, five older students surround her. The oblivious teachers and distracted staff don’t even bother noticing older pupils ridiculing the young girl’s outfit, teasing and tormenting the juvenile girl about her revolting clothes till she cries. Finally after the bell rings for 2nd period the older students leave.It caused the young girl to be more embarrassed and humiliated. Schools all across America should be required to wear school uniforms, because they provide school students with a better school experience. One reason why students should wear uniforms is schools would be a safer place because not many dangers would harm the school. For example, schools â€Å"struggling with gang problems report that school uniforms† (http://www. articlebase. com /advice-articles/pros-and-cons-of-school-uniforms-182. html).Any sort of gang related â€Å"identity or markings would not be an issue† and in â€Å"addition baggy clothing used to hide weapons, drugs or pregnancy would make the lives of teens more transparent and less hidden from adults† (http://www. procon lists. com/list/education/school-uniforms/35). Making students wear school uniforms would make it easier to identify hidden icons that many teenagers hide. Uniforms â€Å"make identification of children who belong to the school and those who don’t easy† (http://www. proconslists. com/list/education/school-uniforms/35).School â€Å"intruders are more easily identified in a school of uniformed children† (http://www. sheknows. com/living/articles/809991/the-pros-and-cons-of-school-uniforms). If we wear school uniforms then you can easily find intruders in school because they will not be wearing uniforms. Therefore, American school students should wear uniforms because dangerous activities and such shall not happen if we wear uniforms. Others might say that students should not wear uniforms, because they are costly. For example, opponents â€Å"contend that school uniforms are an unfair dditional expense for parents who pay taxes for a free public education† (http://www. greatschools. org/find-a-school/defining -your-idea/121-school-uniforms. gs). Uniforms can be expensive, which poor families might not be able to afford. However, one â€Å"school in Seattle found the average cost of clothing a child in a school with uniforms is less than without such a program, sometimes 80 percent less† (2. ed. gov). Schools that choose to have uniforms could choose ones that don’t cost much, so poor families can afford them.As a result, students should wear uniforms, because they are cheaper. Another reason we should wear school uniforms is they cost less because you won’t have to buy or think about clothing for school, For example, school uniforms would save parent’s money, â€Å"the upfront cost of a uniform would be less than a new wardrobe of the â€Å"coolest† styles† (http://www. proconslist. com/list/education/school-uniforms/35). Children who come â€Å"from a less fortunate economic background would not appear to be â€Å"lacking† or made fun of because their parents could not buy them the trendiest garment† (http://www. roconslist/list/education/school-uniforms/35). If we wear school uniforms that are less costly, kids wouldn’t be pressured about clothing. School uniforms would save time both â€Å"parents and their children would not have think about what to wear in the morning and parent save time taking children shopping† (http://www. proconslists. com/list/education/school-uniforms/35). School uniforms â€Å"remove the factors from the social environment within the school the school, thus relieving students from the pressure t o fit in† (http://kids. ovetoknow. com/wiki/Pros_and_Cons_of_School_Uniforms). Therefore, if we wear school uniforms that are less costly, they will save money and time. Thus, making students wear uniforms would be more efficient and a money-saving strategy. Back at the school, the blunt teachers finally notice the juvenile girl crying and ask her what’s wrong. She says nothing because she knew if she told the teachers the older students would just humiliate her more. If students did wear uniforms everybody would be wearing the same thing and

Lifebuoy in the United Arab Emirates Essay Example | Topics and Well Written Essays - 1250 words

Lifebuoy in the United Arab Emirates - Essay Example The Unilever started in Saudi Arabia by appointing Binzagar family as official representative. In 1992, the company decided to open its first office in Dubai followed by a joint venture in Egypt. It was operated in three clusters. In 2007 all the three were combined and became Unilever North Africa and Middle East to consolidate its operations, leverage synergies of scale and cost arbitrage. It is considered as the market leader in the region with a market turnover of US$ 1.3 billion (Unilever North Africa and Middle East Bucks the Global Trend, 2009). The brand Lifebuoy has come a long way through the years. It is one of the country’s oldest brands launched in 1894 as Lifebuoy Royal disinfectant soap. Considered as an affordable soap to support people seeking better personal hygiene, it was launched across the world and continued to be a leading brand in India (Lifebuoy Shampoo). Lifebuoy brand has also a shampoo line which includes variants such as hair fall, herbal and anti dandruff. It was launched in 1997 in Pakistan and a leading brand ever since. It provides affordable shampoo for the Pakistanis regardless of lifestyle and class. Every variant should have a detailed description of the product for consumers’ information. ... Since Middle East is a hot region and majority of the people including in the UAE suffers from dandruff due to heat, diet and other external factors, the market for anti-dandruff shampoo has been lucrative. Most citizens suffer from an age range of 15 years to above 40 years old but the majority of them are between 25 to 29 years old according to research. Different brands of shampoo can be found on the market but has different side effects have been noted on the consumers such as makes the hair hard, bad smell and others. UAE’s development of free zones and other industries such as industrial and commercial sites, growing sectors in healthcare, hotel and restaurant, automotive logistics and construction, it provides large number or workers that are prospective consumers of anti-dandruff shampoo and other products and can be considered as lucrative market Different marketing strategies have been adapted by Unilever Company to market their Lifebuoy products. Vikram (2010) state d that Brand Management is the application of marketing techniques to a specific product to a product line that may be a brand too. Using this kind of strategy, brand management will generate more profit because the brand has been established in the consumers’ mind that they will continue to patronize the new product under that brand. They continue to use brand management through the years because it is a more effective way of introducing new products to market. It is also a cheaper mode of advertisement since the brand is already known by consumers and they do not have a hard time remembering the new product because they can always associated the new products with the famous brand. Another strategy that had been using by the company

Performance Measurement Assignment Example | Topics and Well Written Essays - 250 words

Performance Measurement - Assignment Example Performance measurement is an incessant examining of an outcome with time, frequently for several years, to look for dissimilar signals of change that can be due to different campaigns, programs or initiatives (Chiesa & Frattini, 2009). Evaluation undoubtedly can employ quantitative measures to settle on if the change has occurred or not. But it usually brings qualitative information into the act. With performance measures, change signals in the time sequence of quantitative data are vital. Performance measurement is not a part of the assessment. It is a means that managers use, but not evaluators. Distinct from program evaluation, which calls for an excellent methodological collection and requires the knowledge of trained evalua ­tors, performance measurement is clear-cut. Program objectives along with resultant outcomes are recognized (Chiesa & Frattini, 2009). Another benefit is that measures track results, and data are collected that allow managers and other stakeholders to scrutinize program performance. Performance measures consequently necessary in order to know whether the program is performing where it ought to be. It is then easier to do a program evaluation to find out why it is not meeting the

Management - Report on RSE plc Essay Example | Topics and Well Written Essays - 2000 words

Management - Report on RSE plc - Essay Example After the evaluation, it has been concluded that the marketing division is mainly responsible for the overall planning, promotion, and sales of RSE products. In addition, the responsibility of the human resource department in making necessary changes has been indicated. The following set of recommendations is given to address the current management problems of RSE: take advantage of large opportunities for overseas expansion minimize the threat of economic crisis and trading costs launch an integrated marketing system create general integration and linkage across organizational systems enhance communication networks address organizational weaknesses employ an IT-based human resource system 1. Introduction In the face of the economic crisis, the Strategic Operations of Richard Shaw Enterprises (RSE) could only see the light in the future through expanding the business overseas. Over the last years until its initial public offering in 2006, RSE has been faring well in the UK Stock Exch ange market -- trading at 233p per share, and maintaining a decent profit margin. It had also significantly improved its brand image -- the company is increasingly acknowledged. In fact, its owner and founder, Richard Shaw, was recognized as the â€Å"Businessman of the Year† by the Confederation of British Industry (CBI) in 2000. However, like any other businesses, RSE is not spared from the threat of the economic crisis. Along with this, company is also experiencing serious problems in its business processes primarily in the Marketing Division. In addition, there is also an ongoing problem with regard to the integration and information linkage between the domestic and foreign offices, as well as across the major divisions in the organization. With these issues, this paper seeks to accomplish three things: (1) to report the current status of RSE’s business processes and its emerging business needs, (2) to present detailed information systems solutions that would addre ss such needs, and (3) to explain the relevance of implementing information systems and Internet applications to current business operations of RSE. 1.1 Background (Current Business Processes) Richard Shaw Enterprises (RSE) was founded in the year 1994, and was named after its owner Richard Saw. The company went public by the year 2006, and it has remained competitive in spite of the recession, and the high costs involved with the organization's trading operations. At present, RSE is situated in different locations, namely: Maidstone (Kent), Rome, Paris, as well as in Lagos, Nigeria. It is currently operating in two main trading strands: (1) buy and sell, and customization of shop fixtures, fittings, business machines, and other company equipment, and (2) auctioning of bankrupt office equipment, fixtures, and fittings. To top it all, RSE is equipped with technologically innovative information systems. In order to assist marketing managers in carrying out their functions, particularl y in closely monitoring product selling and distribution, the collateral reporting systems was installed. Moreover, in 1995, a computerized system for the payment of staff salaries was also installed. This was followed by the computerization of sales and purchase order processing in the year 2003. 2. Findings (Current Business Processes) Data used to present these findings were obtained from RSEs strategic review of operations in

Response to Valedictorian Speech- Discussion on high school education Essay

Response to Valedictorian Speech- Discussion on high school education - Essay Example In this discussion about the American education system, the controversial issue is whether the academia has adequately prepared its students for the challenges of higher education. On one hand, Goldson argues that she is graduating at the top of her class only because she did her best to follow what she was told to do within the system that is already set up before her. On the other hand, the academia contends that they stress not only memorization, but also understanding, challenging, and innovating when engaging new ideas. My own view is that the potential to learn and probe cannot be suppressed if we do not allow it. I believe, too, that the academia does not wish to see its students fail to thrive in school. It is about time that people begin to see that grades do not make the person. Such thinking could lead the way towards, hopefully, important and effective

Is International Trade Driven By Theory Essay Example | Topics and Well Written Essays - 1750 words

Is International Trade Driven By Theory - Essay Example Events happen all around us at all times. Life is full of something either happening or not happening. Science makes an attempt to codify the related events and find reasons for events that happen regularly and develops what we understand a theory that describes and informs us of why these events happen or not happens. Kaplan (1964) and Merton (1967) state that theory is the answer to the questions of why. The study of the substance of causal relationships, identification of sequence and the schedules of events are highlighted by the theory which tries to portray systematic reasoning for both occurrences and non-occurrences. A theory is considered as strong when the essential and basic practice or progression is evident and collated. A theory is considered weak if these factors are missing. A theory will essentially be an explanation, a delight and a prediction of events (Weick 1995). This means that there will be the presence of logic, it will calculate, foretell and it will satisfy the curiosity even f it is contrary to expectations. A theory is also multi-directional. It may delve in itself to find deeper or finer meanings or it move in an upward or sideways direction to be a part of another concept. It is not so easy to define a theory, despite the above attempt, but it is easier to state precisely what a theory is not. Sutton and Staw, through the ASQ forum, have very aptly explained that a theory is definitely not references and data. These provide inputs but add no substance or value to the phenomena.

Home Work # 6 Assignment Example | Topics and Well Written Essays - 1000 words

Home Work # 6 - Assignment Example Therefore, an economy undergoes a rapid recovery period which is accompanied by technological advancement. Resources are allocated towards the reconstruction of the damaged capital stock such as foreign aid and human capital. In the short run the aggregate output will grow at a higher rate than the growth rate of the labour force due to the increased savings and foreign aid which pushes the recovery of the capital growth rate back to normal. d) After world war two, the real GDP in Germany and Japan grew steadily due to the period of technological advancement and reconstruction. During the recovery period, the technology in these countries grew at a faster rate leading to the faster growth of effective labour which is translated into their real GDP. 6. With the rise in depreciation, the equilibrium steady-state capital-labour ratio declines.as a result, output per worker becomes lower and that leads to lower consumption of the same worker. This is based on the assumption that the capital-labour ratio is not very high in that an increase in k can reduce consumption of the worker. On the long run, there are no effects on the growth rate of the total capital stock. This is due to the fact that, in the long run, the capital stock should grow at the same rate as the labor rate growth is and therefore the capital-labour ratio remains constant. 7a) The government purchases per worker are indicated by IS at the inintial time, as the government purchases more, the IS curve shifts to IS2 curve which goes up and further to the right of the curve. This shows the increase in both the government spending and also the increase in the interest rate of the government revenue. b). if the government increases g, it will lead to reduction in the savings of the government and therefore capital per worker increases due to increased savings, output per

Greeting Cards Research Paper Example | Topics and Well Written Essays - 1000 words

Greeting Cards - Research Paper Example Greeting cards has the potential to play a pivotal role in maintaining the goodwill of the business. The businesses use them to remind business partners of their presence. When businesses receive greeting cards on and off, they may also feel valued and important for the client. The feeling of importance may allow the business to take further interest in strengthening relationship ties with other clients. The application of greeting cards became modern just like other aspects of our lives. Nowadays, people are sending greeting cards through electronic means, but the people have lost the true taste of receiving them because human mind does not respond well towards online greeting cards in the same way. The human mind and personality internalizes stimulus in print more powerfully than electronic ones. The trend of building and forging social relations is also dying out in the modern era of the 21st century. The humans of modern times are very active on Facebook and they tend to enjoy their experience of socialization on the web. However, they are completely unaware of the fact that they might have thousands of friends on the internet. They do not have a shoulder to lean on in the times of sorrow. The modern friends remain part of one’s life during good times only, and they fly away on sighting the first sign of trouble. That is the difference between conventional friendship and modern one. In historical times, the buddy was even closer than one’s blood relatives (Fischer & Reuber, 2011). The present is witnessing breaking down of social relations that kept the community together. On the other hand, the online socialization sites are making billions by just getting people to place clicks so the humanity is dying out, and economic considerations have become very valuable during the process of selecting friends and partners. Human development and grooming occurred as a result of

Thesis sample Essay Example for Free

Thesis sample Essay Introduction The town of San Antonio is a 2nd class municipality in the province of Nueva Ecija. It is located in between Jaen,Zaragosa, Cabiao and Concepcion. San Antonio is devided into 16 barangays. San Antonio is just an unfrequented place in Nueva Ecija; businesses are well introduced to the public. And since the town starts to compete in the market, varieties of products are opened like services and high quality products. In search for a business to engage at, the researchers considered the continous need of merchandise to be sold. Hardware supplies are items continously needed in search for knowledge and to earn living. The system of management of his business is simple as buying and reselling the items to prospective consumers. But due to present market condition where management is becoming complex due to the emergence of scientific methods of management tries to out-do each other, a need for a â€Å"evaluation study† as a means of preparation and planning is of outmost importance of this study. Venturing into business is the only alternative income and at the same time provide employment even just to a few. Statement of the Problem This research work is aimed to look into the viability of establishing a hardware supplies business in San Antonio, Nueva Ecija. Specifically this study sought answers to the following: 1. Who is the target market of the pruposed business? What are the marketing strategies and programs of this proposed business? 2. What are the technical and production processes needed in the operation of the proposed business? 3. What type of organization is necessary for the proposed business? 4. How much initial capital is (needed) to establish this kind of business? How long did the initial capital paybacked? 5. What are the potential problems that may arise during the operation of the proposed business? What possible solution to these problems? Significance of the study This research work provides the following significance: 1. To The Researchers – It will help the researcher to find if their study will be succesful in the future. 2. To The Students – It will be the guide to the students if they will do their own research. 3. To The Future Investors – It will be their referrence if they will invest to this business or not. Scope And Limitation The E. B De Guzman Enterprises in San Antonio, Nueva Ecija is a family business that engage with hardware products. The scope includes the evaluation of the business in terms of Marketing and Financial Aspect. Marketing Aspect : This study will discuss how the business run. It includes their marketing strategies that made their hardware expanded. Financial Aspect : This study will discuss the profitability of the business. It will present information about the current project income, project cash, project sales and project expenses. Definition of Terms For purpose of being clear and understandable of the terms used in this feasibility study. The following definitions are given:

Monoclonal Antibodies as a Therapeutic Approach for Cancer

Monoclonal Antibodies as a Therapeutic Approach for Cancer INTRODUCTION Monoclonal anti-body cancer therapy is one of the most suitable therapeutic approach for hematologic malignancies and solid tumours for the past several years. This therapy of monoclonal anti-body join target cell, increase immune system, kills affected cells and slows tumour growth in patient. It is a laboratory produce mixture of homogenous anti-body molecules with empathy towards a particular antigen being generated by using a hybridoma by combining a B-cell with a single lineage of cells containing a specific antibody gene. A host of similar cells are produced that secrete the same anti-body. Owing to its specificity and high reproducibility, MAbs are more advantageous over polyclonal antibodies. MAbs are more often used in variety of applications like, research and diagnosis, therapeutic tools in cancer and immunological disorder, pharmacy, etc, as such are in huge demand in industry. Due to its high specificity, MAbs are increasingly used for basic immunological and molecular r esearch and have proven desirability. They are used in human therapy, cancer therapy, diagnosis of disease, commercial protein purification, suppressing immune response, hormone test, diagnosis of allergy, structure of cell membrane, purification of complex mixtures, identification of specialized cells, preparation of vaccines, increasing the effectiveness of medical substances (Edward, 1981). MAbs are used in applications against cancer cell-specific antigens which include an immunological response against targeted cancer cells. Availability of MAbs which recognizes immune cells antigen has resulted in improved diagnosis for lymphoma and leukemia. They are also being used in diagnosis of solid tumour especially for carcinoma of lungs, colon, and rectum. They are also useful in examining blood, sputum, biopsy samples of cancer cells or for materials discharged by cancer cells. At present MAbs are available for variety of cancers like ovarian, colorectal, lungs, etc (Beckman et al, 2007). MAbs interceded immunotherapy employs cells having cytotoxicity like monocytes and macrophages through antibody dependent cell cytotoxicity. MAbs binds complement proteins in cancer therapy which leads to direct cell toxicity that is complement dependent cytotoxicity (Carter, 2001). MAbs stops growth of tumour cells by blocking growth factors thus arresting the spread of tumour cells. MAbs not only detect cancer cells but also destroys them and clinical trials have revealed that MAbs stimulate partial reduction. Conjugate MAbs are combined with drugs and toxins and radioactive atoms are applied as delivery vehicles to take these substances through the body. MAbs flows in the body until it finds cancer cells with a matching antigen and delivers toxic substance to the place of the body. In chemotherapy, MAbs conjugate with chemotherapeutic drugs known as chemo labelled antibodies. The delivered drug causes damage to tumour and normal tissues. Clinical applicability of MAbs is because of its specificity and homogeneity. Another special feature of hybridoma production is that mixture of antigens can be used to produce specific antibodies. The treatment of cancer by MAbs has got highly advanced and its scope as therapeutic agent for untraced cancer has broadened. 2. REVIEW OF LITERATURE 2.1 Production of Monoclonal Antibody The production of MAbs by hybridoma technol ­ogy was first discovered by German scientist, Georges Kohler and Cesar Milstein of Argentina. In 1976 they developed a technique involving fusion of a cancerous (immortal) mouse B-Cell myeloma with an immunized mouse plasma cell by creating a hybrid cell/hybridoma (Blaine, 2012). The hybrid cells are clones of anti ­body producing cells against desired antigen and spread rapidly to generate large amounts of antibody. Hybridoma is capable of rapid circulation and high antibody exuding rates as in myeloma cells, and can maintain antibody genes of mouse spleen cells (figure 1.1).            Figure 1.1: Production of monoclonal antibodies 2.1.1 Outline of production of MAbs The basic approach for production of MAbs includes, viz., purification and characterization of the desired antigen in sufficient quantity, immunization of mice with purified antigen, culture of myeloma cells which are unable to synthesize hypoxanthine-gua ­nine-phosphoribosyl transferase (HGPRT) enzyme necessary for the salvage pathway of nucleic acids, exclusion of spleen cells from mice and its fusion with the myeloma cells, and following fusion growth of hybridomas in hypoxanthine aminop ­terin thymidine (HAT) medium where only the fused cells have the ability to grow. Because of lack of HGPRT, unfused myeloma cell has no ability to grow in this HAT medium, and as such cannot produce DNA. Because of short life spans unfused spleen cells can ­not grow, only fused hybrid cells/hybridomas can grow in HAT medium. Since spleen cell partners produce HGPRT, Hybrid cells have the ability to grow in the HAT medium. Hybrid cells clones are produced from single host cells and the antib odies exuded by the differ ­ent clones are then tested for their capability to combine to the antigen using an enzyme-linked immunosorbent assay (ELISA). And finally then the clone is selected for further use (Zola, 2010). 2.2 Types of Monoclonal Antibodies The various types of anti-cancer monoclonal antibodies are: 2.2.1 Naked monoclonal antibodies Naked MAbs are antibodies that work for themselves and there is no drug or radioactive material connected to them. For cancer treatment, these are the most common type of MAbs. A large number of naked MAbs are attached to antigens on cancer cells but a few of them performs either by joining antigens to the non-cancerous cells or to the free-floating proteins. Naked MAbs works in a diverse manner as elaborated below: Some of them increase patient’s immune response against cancer cells by joining to them and thereafter acting as an indicator for the body’s immune system to destroy them. For instance, Alemtuzumab used against leukemia (Lin T.S, 2008). Some of them targets immune system at checkpoints. While some work by joining and blocking the antigens which are important signals for cancer cells and other cells that help cancer cells grow or spread). E.g. Trastuzumab: used against breast and stomach cancer (Hudis, 2007). Conjugated monoclonal antibodies Conjugated MAbs are antibodies where MAbs are combined to other substance like chemotherapy drug, different type of toxin, or a radioactive particle. Here MAbs are used for taking these substances directly to the cancer cells and mingles in the body until it finds the targeted antigen and delivers the toxic substance at the required place thereby reducing or somewhat eliminating the chance of causing damage to normal cells in other parts of the body. These are also called as tagged, labelled, or loaded antibodies. They are divided into a variety of groups, as given below: Radiolabeled Antibodies These have minute radioactive particles joined to them. E.g. Ibritumomab tiuxetan, acts against CD20antigen (Knox S .Jet al, 1996). Chemolabeled antibodies These have strong chemotherapy (or other) drugs joined to them and are also known as antibody-drug conjugates (ADCs). E.g Brentuximab vedotin (acts against CD30 antigen) attaches to the chemo drug called MMAE. 2.3 Mechanism of Action MAbs apply their antitumor effects by various types of means of action: It directs the immune system to destroy cancer cells where the immune system destroys the foreign invaders in our body but it doesnt identify the cancer cells. MAbs are directed to join to particular parts of a cancer cell and marks cancer cells thereby making it simple for immune system to find like Rituximab (Rituxan) attached to a CD 20 protein on B cells. When Rituximab attaches to the protein on the B cells it makes the cancer cells more detectable to the immune system and make it convenient for it to attack. MAbs targeting Ccncer requires to attach to appropriate tumour cell surface antigens with adequate quantities and lead to destruction of targeted cells (Ignacio Met al, 2007). Mode of action include tumour cell toxicity via antibody-conjugate, modulation of host immune system (such as ADCC/CDC), and blockade of ligand combining and signalling perturbation. By combining with the cytokines or other proteins which are critical for cancer cells for maintaining their uncontrolled growth Cancer cells depend upon blood vessels to give them oxygen and nutrients required for their growth and to attract blood vessels cancer cells send growth signals. MAbs blocks these growth signals and prevent a tumour from maintaining a blood supply to stop growth. In other words, if a tumour has already instituted a network of blood vessels then it blocks the growth signals making the blood vessels to die and resulting in tumour to shrink. E.g. bevacizumab (Avastin) (Margeret VM et al, 2003). It targets a growth signal ,vascular endothelial growth factor (VEGF), which cancer cells sends to attract new blood vessels. It stops a tumours these signals and stops them from connecting with their targets. Delivery of radiation to cancer cells. MAbs are joined with radioactive particles to give radiations directly to the cancer cells. But the drawback is that by this method most of the healthy cells are damaged .E.g. Ibritumomab (Zevalin) It joins itself to the receptors on cancerous blood cells and subsequently delivers the radiation. Delivery of chemotherapy to cancer cells. MAbs are joined J with chemotherapy drugs to give radiations directly to the cancer cells.E.g. Ado-trastuzumab (Kadcyla). It joins to HER2 receptors present on the breast cancer cells and cancer cells consume these antibodies which in turn releases a few molecules of chemotherapy. chemotherapy damages only to the cancerous cells. 2.4 Side effects and limitation of monoclonal antibodies 2.4.1 Side-effects MAbs generally have small side effects unlike chemotherapy. Only a mild aller ­gic reaction or rashes may occur with first admin ­istration of the drug. Other common side-effects are fever, headache, weakness, chills, nausea with vom ­iting, and low blood pressure (Chames p et al, 2009). Whereas grave side-effects are infusion reaction, low blood cells count, heart problem, skin problem and bleeding. Else other side effects of MAbs are with the targeted antigens. Bevacizumab used against tumour blood vessel growth can result in kidney damage, high blood pressure, bleeding with poor wound heal ­ing, and blood clots (Scolnik, 2009). Cetuximab which is used against lungs cancer and head and neck cancer can result in severe infusion reaction and can cause serious rashes. Rituximab which is used against leukemia andlymphoma can cause renal toxicity and serum sickness. 2.4.2 Limitations A serious limitation is that MAbs drugs are most costly as there are only a few FDA regulated drugs which are available in the market. A good number of new MAb drugs are still under development process. Since generic competitors are not there, the sale of cost-effective MAbs is quite good. MAbs are most commercialized and marketed products. Due to huge cost, MAbs therapies are a financial burden on patients. With only proper health planning and step-wise periodic therapies the problem can be sorted. MAbs is a proven therapeutic agent and as acted as mulching cow for the pharma ­ceutical industry. The typical doses of MAb drugs needed for treatment are significantly higher than those required for other drugs. Thus, large-scale production that is cost-effective in man ­ufacturing processes is required. However, the huge demand to increase production of these drugs and the drive to lower the cost of these expensive medicines is a continuous challenge to the present industry. This will further improve the efficiency of manufacturing processes. These challenges are overcome by streamlining downstream processes to increase product quantities, to implement proper quality with high-concentration product formulations with sufficient stability, dose-effective products, to reduce the cost, to develop methodologies for time ­line MAb production, and to develop alternative delivery systems (Rohrer T et al, 2009). 2.5 Monoclonal Antibody Drugs used in Cancer The treatment of monoclonal antibody depends upon the type of cancer and drug you are receiving. Some of the drugs are used in combination with others treatment like chemotherapy and hormone therapy. MAb drugs are used to treat advanced cancer that does not respond to chemotherapy or cancer that had returned. Some of the mAb drugs are: Bevacizumab: Humanized; used against colorectal cancer, breast carcinoma, on-small cell lung cancer and renal carcinoma Rituximab: Chimeric; used against leukemia and lymphoma Cetuximab: Chimeric; used against EGFR-positive metastatic colorectal cancer and carcinoma of head and lungs Trastuzumab: Humanized; used against ERBB2-positive breast carcinoma 2.6 Diagnostic potential of monoclonal antibodies The development of monoclonal antibodies to has provided considerable research of interest. There are monoclonal antibodies which are directed against B cells, natural killer cells, granulocytes, monocytes and platelets. Abs which reacts with different antigens is available which have definite mechanism of action (Khemshead et al, 1983). Several antibodies hare available which react with progenitor cells and these have been used as an aid in the diagnosis of different leukaemias. Neuroblastoma and lymphoma cells may have the appearance of small round cell tumours and be indistinguishable morphologically. MAb react predominantly with these tumour types and used for such diagnostic distinction. Antibodies reacting against tumours when it is coupled with radio label may be used for radioisotope scanning and small metastasis may be visualised using this. MAbs are being used in clinical evaluations and promise to provide a new generation of targeting agent.